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Anti-FBXO31 Antibody

品牌：Antibodies

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規(guī)格：100μl

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Anti-FBXO31 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-FBXO31 Antibody See all FBXO31 primary antibodies
Description:	Rabbit polyclonal antibody to FBXO31
Specificity:	The antibody detects endogenous levels of total FBXO31 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to residues near the C terminal of human F-box protein 31
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.8mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.
Tissue Specificity:	Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow.
Involvement in Disease:	Mental retardation, autosomal recessive 45: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT45 manifestations include mild to moderate intellectual disability and dysmorphic features, including coarse facies, broad nasal bridge, fleshy nares, and thick, prominent lips.
Sequence Similarities:	Belongs to the FBXO31 family.
Post-Translational Modification:	Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.
Database Links:	Entrez Gene: 79791?Human Omim: 609102?Human SwissProt: Q5XUX0?Human Unigene: 567582?Human
Synonyms:	DKFZp434B027 Antibody DKFZp434J1815 Antibody F box only protein 31 Antibody F box protein 31 Antibody F-box only protein 31 Antibody FBX14 Antibody FBX31 Antibody FBX31_HUMAN Antibody FBXO14 Antibody FBXO31 Antibody FLJ22477 Antibody MGC15419 Antibody MGC9527 Antibody pp2386 Antibody Putative breast cancer tumor suppressor Antibody SCF ubiquitin ligase specificity factor Antibody
Information:	Target information shown above is from the UniProt Consortium.