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Anti-FBXO11 Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-FBXO11 Antibody

商品詳情參考文獻相關(guān)資料

Overview

Name:	Anti-FBXO11 Antibody See all FBXO11 primary antibodies
Description:	Rabbit polyclonal antibody to FBXO11.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:100, IF: 1:20 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human FBXO11.
Protein Length:	927
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
Tissue Specificity:	Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
Cellular Location:	Nucleus. Chromosome.
Database Links:	Entrez Gene: 80204?Human Entrez Gene: 225055?Mouse Entrez Gene: 301674?Rat Omim: 607871?Human SwissProt: Q86XK2?Human SwissProt: Q7TPD1?Mouse SwissProt: Q7TSL3?Rat Unigene: 352677?Human Unigene: 386857?Mouse Unigene: 36585?Rat
Synonyms:	F box only protein 11 Antibody F box protein 11 Antibody F-box only protein 11 Antibody FBX11 Antibody FBX11_HUMAN Antibody FBXO11 Antibody PRMT9 Antibody Protein arginine N methyltransferase 9 Antibody Ubiquitin protein ligase E3 component n recognin 6 Antibody UBR6 Antibody UG063H01 Antibody VIT 1 Antibody VIT-1 Antibody VIT1 Antibody Vitiligo associated protein 1 Antibody Vitiligo associated protein VIT 1 Antibody Vitiligo-associated protein 1 Antibody
Information:	Target information shown above is from the UniProt Consortium.